Scotland no. 8 Donna Kennedy is on course to claim her 100th cap after being named as captain for the opening RBS Six Nations game against England on Saturday 3 February.
Kennedy will make her 96th appearance for Scotland at Old Albanians RFC, St Albans this weekend and could make her century in the final match against France on March 17.
Full-back Lucy Millard has been named as vice-captain for the game where new coach Lee Adamson takes charge for the first time.
Lock Louise Moffat, centre Donna McGrellis and wingers Tanya Griffith and Cara D'Silva will all make their Scotland debuts.
Scotland Women's team to face England in the RBS Six Nations at Old Albanians RFC on Saturday 3 February (kick-off 2.30pm)
15 Lucy Millard (Murrayfield Wanderers)
14 Cara Dâ€™Silva (Kirkcaldy)
13 Donna McGrellis (Kirkcaldy)
12 Suzi Newton (Blaydon TN)
11 Tanya Griffith (Royal High Corstorphine)
10 Erin Kerr (Richmond)
9 Louise Dalgliesh (Royal High Corstorphine)
1 Lynne Reid (Royal High Corstorphine)
2 Gail Russell (Richmond)
3 Jilly McCord (Royal High Corstorphine)
4 Lindsay Wheeler (Murrayfield Wanderers)
5 Louise Moffat (Kirkcaldy)
6 Heather Lockhart (Hillhead Jordanhill)
7 Susie Brown (Hillhead Jordanhill)
8 Donna Kennedy (Royal High Corstorphine, CAPTAIN)
16 Sarah-Louise Walker (Watsonians)
17 Beth Dickens (Murrayfield Wanderers)
18 Lana Blyth (Murrayfield Wanderers)
19 Sonia Cull (Royal High Corstorphine)
20 Rachael Nicolson (Hillhead Jordanhill)
21 Anna Panaytopoulos (Edinburgh Uni)
22 Hazel Bielinski (Hillhead Jordanhill)