Stand-off Tanya Griffith returns to the starting XV as Scotland Women regroup to take on their Irish counterparts at Ashbourne RFC on Friday 9 March (kick-off 7.30pm).
Head coach Karen Findlay said: "Ireland will be a massive challenge away from home. Both teams will look to play rugby and to defend hard so it should be a good game."
Hooker Alison Macdonald, back row Tess Forsberg and stand-off Lisa Martin move to the bench, completing the four changes to the side that was defeated by France at Bridgehaugh two weeks ago.
Ireland go into the game on the back of a 36-0 win in their rescheduled game against Wales last weekend while the Scots are seeking their first Championship points of the season.
Scotland Women v Ireland Women on Friday 9 March at Ashbourne RFC, kick-off 7.30pm
15 Stephanie Johnston (RHC Cougars)
14 Katy Green (Murrayfield Wanderers)
13 Laura Steven (Murrayfield Wanderers)
12 Lisa Ritchie (Carlisle)
11 Sarah Dixon (Stirling County)
10 Tanya Griffith (RHC Cougars)
9 Louise Dalgliesh (RHC Cougars)
1 Tracy Balmer (Worcester)
2 Sarah Quick (Murrayfield Wanderers)
3 Beth Dickens (Murrayfield Wanderers)
4 Anna Swan (RHC Cougars)
5 Jemma Forsyth (Hillhead/Jordanhill)
6 Lindsay Wheeler (Richmond)
7 Ruth Slaven (Murrayfield Wanderers)
8 Susie Brown (Richmond) (captain)
16 Alison Macdonald (RHC Cougars)
17 Heather Lockhart (Hillhead/Jordanhill)
18 Katherine Muir (Richmond)
19 Charlotte Veale (London Wasps)
20 Tess Forsberg (Richmond)
21 Lisa Martin (Murrayfield Wanderers)
22 Lauren Harris (Melrose)
Scotland Women's RBS 6 Nations fixtures are as below, with free entry at both home matches.
Sunday 5 February, Scotland 0 - 47 England
Sunday 12 February, Wales 20 - 0 Scotland, Cross Keys RFC
Saturday 25 February, Scotland 0 - 23 France, Stirling County RFC
Friday 9 March, Ireland v Scotland, Ashbourne RFC, kick-off 7.30pm
Sunday 18 March, Italy v Scotland, Rovato Stadium, Brescia, kick-off 2.30pm (local)