With just seven rounds left in the regular season of the RaboDirect PRO12, the race is well and truly on for a top four finish, and qualification for the Play-Offs.
In the pick of the games this weekend, first plays second when leaders Ulster travel to face Glasgow Warriors at Scotstoun on Friday night.
Glasgow are one of the form teams of the moment, their 60-3 humbling of Dragons at Rodney Parade last time out the biggest away win in the history of the competition.
Close on their heels comes the third versus fourth-placed game on Saturday, when Leinster host Scarlets at the RDS.
Currently there is just a three point gap between the teams, so victory is a must for either side; Leinster could pull away from their nearest rival or, should the result go the other way, Scarlets could take over Leinster's position in the table.
Just outside the top four, Ospreys and Munster know that every game counts in their push for a Play-Off spot.
Munster have won their last three away games and must be hoping that their trip to Stadio Monigo to take on Benetton Treviso will end better that it did two years ago, when they suffered their only loss to the Italian outfit.
Having lost out on the road to Connacht last week, Ospreys will be hoping to maintain their home record when they face Edinburgh Rugby on Friday night.
Edinburgh have not won since a trip to Connacht in December, but have at least managed a victory in Wales this season, beating Cardiff Blues 21-19 in September, and bettered Ospreys at Murrayfield when the clubs clashed in October (23-13).
Should the Scotsmen win the match, it would be the first Welsh double since the 2008/09 season.