Duncan Weir (pictured), the 21-year-old Glasgow Warriors stand-off, will make his first start for Scotland in Saturday's RBS 6 Nations Championship match against Wales at Murrayfield.
Weir, whose three previous caps have been won from the bench, replaces his clubmate Ruaridh Jackson in the pivotal position."
Weir said: "It's a moment I'll cherish and hopefully I can do the coaches justice for giving me the start."
The other change to the initial line-up from the team that defeated Ireland last month sees the 2009 British and Irish Lion, Euan Murray, return to the tighthead berth with Geoff Cross moving to the bench.
Ryan Wilson, the 23-year-old Glasgow Warriors No 8 who has led his club on three occasions this season and who was captain and man of the match in Scotland A's victory over England Saxons last month, is introduced to a match-day 23 for the first time.
Wilson is named instead of David Denton who sustained a knee injury when playing for Edinburgh Rugby against Scarlets in the RaboDirect PRO12 at the weekend.
|Scotland team to play Wales|
RBS 6 Nations Championship at Murrayfield
Saturday 9 March (kick-off 2.30pm)
15 Stuart Hogg (Glasgow Warriors) 13 caps
14 Sean Maitland (Glasgow Warriors) 3 caps
13 Sean Lamont (Glasgow Warriors) 74 caps
12 Matt Scott (Edinburgh Rugby) 10 caps
11 Tim Visser (Edinburgh Rugby) 8 caps
10 Duncan Weir (Glasgow Warriors) 3 caps
9 Greig Laidlaw (Edinburgh Rugby) vice-captain, 16 caps
1 Ryan Grant (Glasgow Warriors) vice-captain, 8 caps
2 Ross Ford (Edinburgh Rugby) 66 caps, 2 tries
3 Euan Murray (Worcester Warriors) 51 caps
4 Richie Gray (Sale Sharks) 30 caps
5 Jim Hamilton (Gloucester) 44 caps
6 Robert Harley (Glasgow Warriors) 3 caps
7 Kelly Brown (Saracens) captain, 55 caps
8 Johnnie Beattie (Montpellier) 19 caps
16 Dougie Hall (Glasgow Warriors) 41 caps
17 Moray Low (Glasgow Warriors) 17 caps
18 Geoff Cross (Edinburgh Rugby) 19 caps
19 Alastair Kellock (Glasgow Warriors) 50 caps
20 Ryan Wilson (Glasgow Warriors) uncapped
21 Henry Pyrgos (Glasgow Warriors) 5 caps
22 Ruaridh Jackson (Glasgow Warriors) 18 caps
23 Max Evans (Castres) 34 caps
Scotland interim head coach Scott Johnson said: 'selection is tough just now but that's a good thing as we increase competition for places.
'duncan did well when he came on against Ireland and he got some decent game time for Glasgow at the weekend. He's a talent with a really good work ethic and a thirst to improve, which I like a lot.
"Ruaridh remains a key part of our squad but he knows with Tom Heathcote proving a match-winner for Bath and kicking goals from here, there and everywhere, that he needs to up his game too.
"Geoff (Cross) was a standout against Ireland and it's up to Euan, who fronted up big time against Italy, to raise the bar again.
"Wales will be going for their fifth successive away victory in the championship and that would be a record for them but our focus is on ensuring we win the contact zone, continue to improve and make it three wins on the bounce."
Unavailable through injury
: Chris Cusiter and Chris Fusaro (both Glasgow Warriors), David Denton, Grant Gilchrist and Ross Rennie (all Edinburgh Rugby)
Referee: Craig Joubert (South Africa)._ Assistant referees: Glen Jackson (New Zealand) and Lourens Van Der Merwe (South Africa). TMO: Giulio De Santis (Italy).