The focus returns once again to the RaboDirect PRO12, after two weeks of European competition, with Irish Provinces topping three of the six Heineken Cup Pools.
Ulster are the tournament's only team with a 100 per cent winning record, garnering 18 pool points in the process.
Munster and Leinster also top their respective pools, while Cardiff Blues, the top-placed Welsh Region, are only two points shy of pool leaders and reigning champions Toulon.
The Irish provinces are faring well in the RaboDirect PRO12 as well, with three of the four Play-Off places taken up by them, Munster pulling out a four-point lead at the top of the table as the half-way point of the season approaches.
Munster are in action at Musgrave Park on Saturday evening when they face Scarlets, the Welsh region having won at this venue last time they visited.
The round starts off on Friday night with the remaining three teams currently in the Play-Off Zone – Leinster, Glasgow Warriors and Ulster - all in action.
Second placed Leinster travel to Murrayfield buoyed by the fact they have won their last five contests with their hosts but seeking to right the wrongs of their Heineken Cup reverse by Northampton in front of over 40,000 of their home fans.
In Glasgow, Benetton Treviso are the visitors.
Having led in the early part of the season, Warriors now reside in third place in the table (level on points with Ulster) and need a win to keep their season on track.
The remaining top-four team, Ulster, will be looking to maintain their near perfect record against Italian teams when Zebre run out at Ravenhill.